ASUS's latest motherboard is the E3 Pro Gaming V5. Designed with the LGA1151 socket and C232 Express chipset, it's the first ASUS motherboard compatible with Intel Xeon E3-1200 v5 processors, though it supports 6th-generation Intel Core, Pentium, and Celeron processors as well.
The V5 supports DDR4 (4x DIMMs, up to 64GB DDR4 2133MHz) and quad-GPU setups, and features USB 3.1 Gen 2 Type-A and reversible USB 3.1 Gen 2 Type-C (14 ports with data transfer speeds of up to 10Gbit/s) as well an M.2 connection for your SSD. Speaking of storage, up to six SATA drives at 6Gbps are supported.
For cooling, it packs a dedicated water pump header. On the audio front, you get SupremeFX for high-quality audio and a 115dB signal-to-noise ratio. Meanwhile, Intel Gigabit Ethernet technology is said to offer "exceptionally high" TCP and UDP throughput, allowing the CPU to do work harder for the game outside of networking tasks.
ASUS is putting a lot of emphasis on protection with the E3 Pro Gaming V5, packing in anti-EMI surface-mounted capacitors, electrostatically-guarded and surge-protected components which make static electricity and power surges less of an issue, a Digi+ voltage-regulator module (VRM) for "ultra-clean power delivery", DRAM Overcurrent Protection with resettable fuses, high-quality chokes, capacitors that can handle high temperatures, a corrosion-resistant stainless-steel I/O panel (in case you plan on doing any computing near a nuclear power facility), and electrostatic discharge guards.
The V5 should be available now or soon in the UK for £118.10 (about $175). Other regions should come before long.