Longer human lifespan linked to these genes, new research shows

Researchers from University College London have found an association between the Pol I and Pol III genes and longer lifespans.

@AdamHuntTT
Published Wed, Jan 26 2022 2:00 AM CST   |   Updated Tue, Feb 22 2022 4:02 AM CST

A new study describing the link was published in the journal Genome Research.

Longer human lifespan linked to these genes, new research shows 01 | TweakTown.com

The genes that could extend the lifespan of small organisms, such as fruit flies living ten percent longer, have now been found by the University College London (UCL) researchers to demonstrate a similar effect in humans. The genes are related to the creation of proteins in our cells and appear to be an example of antagonistic pleiotropy, where genes that help us in early life and through to child-bearing are selected for by evolution, despite ultimately shortening our lives.

"We have already seen from extensive previous research that inhibiting certain genes involved in making proteins in our cells, can extend lifespan in model organisms such as yeast, worms and flies. However, in humans, loss of function in these genes has been seen to cause diseases, such as developmental disorders known as ribosomopathies. Here, we have found that inhibiting these genes may also increase longevity in people, perhaps because they are most useful early in life before causing problems in late life," said co-lead author Dr. Nazif Alic from the UCL Institute of Healthy Ageing.

The researchers used genetic data from previous studies involving 11,262 people who lived very long lives, to ages above the 90th percentile for their cohort. They found genes linked to two RNA polymerase enzymes, Pol I and Pol III, and some ribosomal protein genes that had reduced activity and were correlated with a likelihood of living longer.

They also found that the longevity increase went beyond associations with any specific age-related disease. This research provides evidence that drugs such as rapamycin, which acts to inhibit Pol III, may help promote a healthy lifespan.

You can read more from the study here.

Buy at Amazon

AncestryDNA: Genetic Ethnicity Test, Ethnicity Estimate

TodayYesterday7 days ago30 days ago
$99.00$99.00$99.00
* Prices last scanned on 5/23/2022 at 2:28 am CDT - prices may not be accurate, click links above for the latest price. We may earn an affiliate commission.

Adam grew up watching his dad play Turok 2 and Age of Empires on a PC in his computer room, and learned a love for video games through him. Adam was always working with computers, which helped build his natural affinity for working with them, leading to him building his own at 14, after taking apart and tinkering with other old computers and tech lying around. Adam has always been very interested in STEM subjects, and is always trying to learn more about the world and the way it works.

Newsletter Subscription

Related Tags

Newsletter Subscription
Latest News
View More News
Latest Reviews
View More Reviews
Latest Articles
View More Articles