Major depression treatment with psilocybin effective for up to a year

Patients who underwent psilocybin-assisted psychotherapy to treat major depressive disorder were in remission for up to a year.

@AdamHuntTT
Published Wed, Feb 16 2022 5:21 AM CST   |   Updated Mon, Mar 14 2022 5:42 PM CDT

A new study on psilocybin's effect in the treatment of major depressive disorder has been published in the Journal of Psychopharmacology.

Major depression treatment with psilocybin effective for up to a year 01 | TweakTown.com

Researchers from the Johns Hopkins University School of Medicine have previously demonstrated psilocybin's ability to relieve symptoms of major depressive disorder in adults for up to a month. A follow-up study of the same participants has shown "substantial antidepressant effects" that can last for at least a year in some patients after psilocybin-assisted psychotherapy treatment.

"Our findings add to evidence that, under carefully controlled conditions, this is a promising therapeutic approach that can lead to significant and durable improvements in depression," says Natalie Gukasyan, M.D., assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine.

"The results we see are in a research setting and require quite a lot of preparation and structured support from trained clinicians and therapists, and people should not attempt to try it on their own," Gukasyan continued.

The study followed 27 participants with a long-term history of depression, where 88% had been previously treated with standard antidepressant medications, and 58% using antidepressants for current depressive episodes. To assess depressive symptoms, the GRID-Hamilton Depression Rating Scale was used, where a score of 24 or more indicates severe depression, 17-23 moderate depression, 8-16 mild depression, and 7 or less no depression.

For most participants, their scores decreased from 22.8 before treatment to 8.7 one week in, 8.9 at four weeks, 9.3 at three months, 7 at six months, and 7.7 twelve months after treatment. Participants responded during the follow-up period with a 75% response rate, and remission of symptoms was at 58% by the twelve-month mark.

"Psilocybin not only produces significant and immediate effects, it also has a long duration, which suggests that it may be a uniquely useful new treatment for depression," says Roland Griffiths, Ph.D., the Oliver Lee McCabe III, Ph.D., Professor in the Neuropsychopharmacology of Consciousness at the Johns Hopkins University School of Medicine, and founding director of the Johns Hopkins Center for Psychedelic and Consciousness Research.

"Compared to standard antidepressants, which must be taken for long stretches of time, psilocybin has the potential to enduringly relieve the symptoms of depression with one or two treatments," Griffiths continued.

You can read more from the study here.

Buy at Amazon

Taking Back My Mind: My Journey Out of Depression with Psilocybin

TodayYesterday7 days ago30 days ago
$14.99$14.99$14.99
* Prices last scanned on 5/23/2022 at 11:43 pm CDT - prices may not be accurate, click links above for the latest price. We may earn an affiliate commission.

Adam grew up watching his dad play Turok 2 and Age of Empires on a PC in his computer room, and learned a love for video games through him. Adam was always working with computers, which helped build his natural affinity for working with them, leading to him building his own at 14, after taking apart and tinkering with other old computers and tech lying around. Adam has always been very interested in STEM subjects, and is always trying to learn more about the world and the way it works.

Newsletter Subscription

Related Tags

Newsletter Subscription
Latest News
View More News
Latest Reviews
View More Reviews
Latest Articles
View More Articles