Microsoft has just released its new Cumulative Update for Windows 10 (KB3213986) which has broken multi-screen gaming, with the company noting that there are "known issues".
This means gamers that are running triple-display setups with AMD EyeFinity and NVIDIA Surround Sound will experiencing stuttering or clipped screens when running a game, but it should be fine in 2D applications. There's a workaround for this issue, with Microsoft adding that gamers can run their 3D apps in non-fullscreen mode - either in window-maximized, or just windowed modes.
But it gets better. Microsoft suggests that gamers disconnect their other displays, leaving just a single display connected to the PC for the game to work. Because, you know - that's why you spend thousands of dollars for the bleeding edge of high-end gaming, to disconnect those expensive LCDs.
Microsoft notes in the change log for KB3213986: "Users may experience delayed or clipped screens while running 3D rendering apps (such as games) on systems with more than one monitor. To work around this issue please consider the following options: 1. Running the application in Windows mode (not full screen), or 2. Starting the application with only one monitor connected".