Power Saving Settings
Most motherboard vendors have decided to call AMD's advanced CPU features the same thing. So AMD's Cool'n'Quiet can be disabled if you want to disable the CPU's low-power c-states and you can disable C6 as well if you want. On Intel platforms, many users disable virtualization to help increase stability (I tend not to bother), and on AMD SVM is virtualization.
Vendors have taken it upon themselves to make up their own memory profile names. XMP (ASRock/GIGABYTE), D.O.C.P., and A-XMP are all the same thing. They enable a profile built in the memory module to automatically overclock it. It's a good idea on all motherboards to manually set DRAM voltage, and sometimes you need to set the DRAM voltage for each channel. DRAM voltage, frequency, and primary timings can be found on the DRAM module's sticker.
While AGESA 18.104.22.168 brought on a ton of more timings, many users might not understand the complexity of those timings and might just opt to change primary timings you see above. On some motherboards memory profiles might not work, in that case, you need to manually set your memory frequency and primary timings.
If you want to tweak the new timings and other features like gear-down mode, you can read AMD's block post found here. There is also a DDR4 PHY voltage, I see it more often on Thread Ripper motherboards, it's called CLDO_VDDP, and AMD states this voltage can solve some memory frequency holes. It's an offset voltage you can take up and down (both can be useful). It should be configured to DIMM voltage -0.1v, but you aren't to exceed 1.05v offset on this.