The Mac Pro Killer Build Guide, featuring Supermicro and Intel (Page 4)
The first step is to compare the holes on the motherboard and install the case standoffs accordingly. Pay close attention as you don't want the blocked E-ATX mounting holes sitting on conductive standoffs in the top left corner or center of the motherboard.
The rear IO shield needs to be installed before you install the motherboard, as it is one of the most forgotten steps in PC building.

Our water cooler weighs a significantly amount, and as you can see needs very strong mounting.
We always opt to install all-in-one water coolers before the motherboard. It is also useful to pre-position your power and data cables.
We like to install DRAM, M.2 drives, and CPUs on the motherboard before installing the board into the case. In the case of the LGA-3467 socket, there is no socket hold down, in most cases you are supposed to mount the CPU to an enterprise cooler, but in this case we opted to put the CPU in the socket once we installed the motherboard, and then install the cooler.
Cabling is also very important, once you get all the power and data cables attached you can then snag extra and tighten things up at the back of the case to improve airflow. Airflow is very important with a machine this powerful and higher temperatures, even by 5-10C can greatly affect the longevity of your hardware.
Here we have our system all installed and ready to go, what a beauty.
