The first thing you'll want to do is to locate the Molex and IDE connectors in the enclosure framework. It doesn't take a rocket scientist to figure out that you're going to want the corresponding end of the hard drive to be sitting in this same position. Once you've got that arranged, you're ready to begin putting the drive in the enclosure.
Once you've set the hard drive into the central portion of the enclosure, use the provided screws to secure it into the framework. The four holes on the bottom are industry standard and also have a slotted design to handle a drive that is just a bit off. Don't tighten everything down just yet, though.
Next you'll attach the included cabling. These parts are designed for this LanDisk device, so lengths are ready to accommodate your hard drive. The reason you didn't want to tighten down the mounting screws is because after you attach the cables, you want to push the drive into the framework just a bit. If you'll take a closer look at the Molex connector pictured above, it sticks out just a bit from the edge of the carriage. This did not allow me to insert the frame into the external enclosure, so I had to loosen the mounting screws and slide it in a bit. Hopefully this will save you a step.
For those who have a keen eye, you've already noticed that the drive is set as a Master device. Make sure that you either remove jumpers or set them accordingly to make it a Master drive.
From here, you insert the drive into the enclosure, hook up the cables and power the device on. Once you have power and the network sees the drive, you're almost home.
As a side note, you can use the included network cable regardless if you're using a router/switch or if you're hooking straight into a LAN port on the machine. The internal circuitry creates a true network so you don't need a crossover cable for hooking directly into your computer.
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