Out of the box I found the El'Druin a bit different to look at aesthetically, but to be honest, I was a bit surprised to feel that it seems so natural under your hand. With the drop off in front of the mid-section before you reach the left and right click buttons, I thought it would feel a bit funky, but it really doesn't. Where I did find a bit of personal discomfort was in the palm plates. The Heaven plate is much closer to the height of the mid-section of the mouse and makes for a very comfortable feel, whether you use the painted one or the rubberized one, both suit this mouse very well. The Inferno plates on the other hand, while they are a bit differently shaped, the drop from the mid-section of the mouse just made this feel "funny" to me. Not in a make me laugh sort of way, but it just didn't feel normal with a high mid-section and nothing near it to help support your hand there. While the rubberized versions of both plates do help keep the mouse in the palm of your hand, even if things get a bit heated, I tended to use the painted plastic version long term with mine.
During the use of the El'Druin, there was nothing out of the ordinary that pops right into my mind. In all honesty, even playing around with the profiles, setting up personal profiles and Macros were simple and the software being very intuitive really helps there. The one thing that is a bit odd about it is when you do apply the settings, the mouse becomes inactive for about ten seconds, as the software sets the mouse. While not detrimental, I have seen much faster in many other mice. Even as far as the DPI is concerned, I found the 2800 DPI that Leetgion set the mouse to as the default is truly the sweet spot for this mouse. While every user varies in their needs here, I found it to be the most productive setting as I wasn't overshooting the small drop down menus and various controls while I edit photos. Unless I was in a game like BF3 where DPI on the fly is very handy, I didn't really see a need to move it at all, no matter the title I was playing.
Getting used to 12 uniquely arranged buttons is something that even after two weeks I still have to peek at the twist open guide to remember what does what, it just takes a bit of time to fully get used to this arrangement. Lastly, while I like that there is a profile button on the side of the mouse, and while typically it doesn't need swapped out in game, that button on the right is awkward to use with a pinky finger, and usually takes me lifting the mouse and using two hands to adjust it. While it is much better than a dial under the mouse like in the Hellion, it is still almost as if it was a secondary addition and not thought out that well.
You do get quite a bit for the money. I am stating this based on the MSRP of $89.95. There is very good software, the mouse does feel good in your hand and is relatively light, making it easy to move around. Functionally, once you have this personalized, I found my time with it productive at the desktop level and accurate with plenty of buttons within reach of my thumb and first three fingers. There were times I overshot weapons selections with the less tactile scroll wheel, but then again this isn't made with FPS games in mind either. I really do think that if Leetgion were to look harder at the way they engineer the profile selection systems on their mouse, there would be no reason to even pick on these designs, but it is there, and was sort of a pain to use.
Would I pay the near $100 price that Amazon is asking? No, I would not. I am hoping that there is some competition soon that sends pricing at least down to the MSRP, and maybe even a bit below. When or if that happens I strongly suggest that you seriously consider the El'Druin laser mouse, but as it sits currently, there are a couple things that need addressed for even the most hardened Diablo III players to really consider this mouse as a "must have".