The Sabertooth was about as easy as any motherboard to get setup and running. We had no issues installing Windows with our USB flash drive as we have on a few other boards (although most of them turned out to be an issue with our KVM). We do have a complaint that is not limited to ASUS, though. For some reason most system BIOSes will default to having the HDD become drive 0 over the SSD. This is even if the SSD is attached to SATA port 1 (or 0 in some cases). This means that when you install Windows, even if you tell it to install on the SSD it will put the boot partition (about 100MB) on the HDD as it is drive 0.
I wish that boards would not do that, as the SSD is becoming more common and should be allowed to take the Drive 0 position. Other than that one complaint (which again I will say is not limited to ASUS), we found the installation to be very simple.
ASUS does have one of the better installers available, although I wish they would extend the InstallAll to allow you to include some of the utilities. This would get them all out of the way at once.