Setup and Installation
The Cine5 is not an overly complex beast and should not provide any substantial difficulties when being set up.
The controls for the system are a fairly simple affair, so there really isn't need for any calibration to be done when setting up. But it's probably a good idea to set your Windows volume level and/or soundcard volume to about 85% and then use the Cine5 control to act as your master dial.
This will just save a bit of messing around with juggling more than one control at a time. Also, be sure that your soundcard is set to 5.1 to avoid confusion.