The X58A-UD7 was cramped. Yes, much of that has a reason or an alternate purpose, but there were some items that were just annoying. The placement of the 4-pin aux power connector resulted in more than a few cuts to my already scarred fingers. But overall, after getting past that I did not have too many headaches based on the layout.
However, I did have a rather odd one. When I first received the X58A-UD7 I installed the OS to it in the same way I always have. This is to just use my USB flash drive based copy of Windows 7 x64 Ultimate. When I did this, however, I began to have problems. The board would randomly reboot, the installation would crash with a blue screen and a number of other issues would occur. We tried a number of fixes but nothing seemed to help.
The really odd part was when we used a traditional DVD there were no problems at all. The install went through perfectly. However, with the release of the F6 version of the BIOS that annoying little issue was fixed. I am not sure what did it, but I can say that I have not had that problem with the board since.
If you do get this board, I would highly recommend flashing it to at least the F6 BIOS as soon as possible. Another important note is that the X58A-UD7 takes a while to boot up. It is much slower than other motherboards in its price range. This has to do with the Marvell SATA 3.0 RAID controller on the board. Still, it is annoying at times and more than once made me think that I had pushed my overclock too far.