The setup and configuration of this board was a snap. I had no problems at all getting everything to play nicely. The spacing on the slots is great and even the vertical SATA ports did not cause any issues. Overclocking the P55DE3 was laughably simple, as I mentioned before (as well in other ASRock reviews), I simply picked the highest EZ OC setting and pushed the BCLK up from there until I topped out.
I do wish they had dropped a PATA port onto this board, but PATA CD/DVD-ROM drives are slowly disappearing and the SATA ones are getting very cheap and beginning to perform comparably to the older PATA style drives now (although there are some that still perform horribly). Still, with the nice and clean layout we had no issues of any importance to note during our testing of the ASRock P55DE3.