In today's market it's getting harder and harder to choose a motherboard. Back about five years ago overclocking was king and companies like ASUS and ABIT had the market cornered. Today overclocking still holds its allure, but just about every board you buy has some degree of overclocking to it, so it's a matter of getting some serious power out of your boards. ASUS does it, MSI does it and GIGABYTE does it hardcore style.
The EP45-Extreme has the most impressive array of voltage options I have ever seen on any motherboard out there. They are also practical, allowing for tweaking of the smallest thing on the board; allowing for a much better and stable tune. Not only that, the tweaking options don't require a degree in rocket science to understand what they are controlling.